Coleus Forskohlin Extract with Forskolin CAS 66575-29-9

• Certification: RoHS, ISO, FDA
• Assay Method: HPLC, UV
• Application Form: Tablet, Capsule
• Application: Health Care Products, Medicine
• State: Powder
• Extract Source: Cordate Houttuynia
• Model NO.: TY-02ALI
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Forskolin
Origin	66575-29-9
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Forskolin
CAS:66575-29-9
MF:C22H34O7
MW:410.5
EINECS:266-410-9
Mol File:66575-29-9.mol  
Melting point:282-232 °C
alpha D25 -26.19° (c = 1.68 in CHCl3)
Boiling point:520ºC
Density 1.23
refractive index 1.5300 (estimate)
Flash point:172ºC
storage temp. −20°C
solubility DMSO: 5 mg/mL stable at least 6 months at room temperature
pka11.00±0.70(Predicted)
form powder
color off-white
Water Solubility Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.




Description

Chemical PropertiesColorless Crystalline Solid
UsesForskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
Usesglucocorticoid, antiinflammatory
Usesadenylate cyclase activator, antiglaucoma, hypotensive, vasodilator
UsesCyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]
UsesAn adenylate cyclase activator and MAP kinase inhibitor
UsesIn purification of adenylate cyclase.

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