Product name |
Podophyllotoxin |
Origin |
518-28-5 |
Appearance |
white powder |
Assay |
99% |
Storage |
Cool and Protect from light |
Product Name:Podophyllotoxin
CAS:518-28-5
MF:C22H22O8
MW:414.41
EINECS:208-250-4
Mol File:518-28-5.mol
Melting point:183-184 °C(lit.)
alpha -110.7 º (c=1, CHCl3)
Boiling point:453.31°C (rough estimate)
Density 1.2649 (rough estimate)
refractive index 1.4480 (estimate)
storage temp. 2-8°C
pka13.26±0.40(Predicted)
form Powder
color White to off-white
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Description
Chemical Propertiesoff-white fine crystalline powder
UsesSkin treatment for genital warts caused by some types of HPVs.
Usesantineoplastic, inhibits microtubule assembly, and human DNA topoisomerase II; antimitotic agent
UsesPodophyllotoxin is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. It binds to topoisomerase II during the late S and early G2 stage, blocking tubulin polymerization and, thus, inhibiting mitosis. In addition to being used as a cathartic, purgative, antiviral agent, vesicant, and antihelminthic, podophyllotoxin is the starting material for the semi-synthesis of the anti-cancer drugs etoposide , teniposide , and etopophos
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