| Product name |
Huperzine A |
| Origin |
102518-79-6 |
| Appearance |
white powder |
| Assay |
99% |
| Storage |
Cool and Protect from light |
Product Name:(-)-Huperzine A
CAS:102518-79-6
MF:C15H18N2O
MW:242.32
EINECS:600-320-6
Mol File:102518-79-6.mol
Melting point:211-216oC
alpha D -147° (c = 0.36 in CH3OH) (Ayer); D24.5 -150.4° (c = 0.498 in MeOH) (Liu)
Boiling point:505.0±50.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. −20°C
pka12.25±0.60(Predicted)
form neat
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Description
Huperzine A is a natural plant alkaloid that extracted from the Chinese medicine Huperzia serrata under the genus Huperzia. It is a potent, revisable and highly selective second generation of acetylcholinesterase inhibitors, with the appearance of yellow to white crystalline powder, and is freely soluble in chloroform, soluble in methanol and ethanol, slightly soluble in water, with high lipid solubility. It is a small molecule that can well penetrate the blood brain barrier, and after entering the central nervous, it distributes more in the brain's frontal lobe, temporal lobe, hippocampus and areas that are closely related to learning and memory. It has a strong inhibitory effect on acetylcholinesterase (AchE) at a low dosage, significantly increasing the content of acetylcholine (Ach) in neural synaptic cleft in the distribution area, thus enhancing neuronal excitatory transmission, strengthening the excitement of learning and memory in the brain, thereby with the function of improving cognitive function, enhancing memory retention and promoting memory reproduction. It is currently the most successful development of Alzheimer's disease (senile dementia) drugs.
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