Product name |
Halobetasol propionate |
CAS |
66852-54-8 |
Appearance |
white powder |
Assay |
99% |
Storage |
Cool and Protect from light |
Halobetasol propionate
Product Name Halobetasol propionate
CAS 66852-54-8
MF C25H31ClF2O5
MW 484.96
EINECS 686-247-0
MOL File 66852-54-8.mol
Chemical Properties
Melting point 213-215°C
Boiling point 570.7±50.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Refrigerator
pka 12.55±0.70(Predicted)
CAS DataBase Reference 66852-54-8(CAS DataBase Reference)
Usage And Synthesis
Description
Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both antiinflammatory and antihyperplasia properties. The compound is recommended for the treatment of moderate to severe corticosteroid-responsive dermatoses and appears to be particularly effective in patients with plaque psoriasis.
Description
Halobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.
GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
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