Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil

• CAS No.: 145040-37-5
• Formula: C33h34n6o6
• EINECS: 627-030-2
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Candesartan cilexetil
CAS	145040-37-5
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Candesartan cilexetil
Product Name Candesartan cilexetil

CAS 145040-37-5

MF C33H34N6O6

MW 610.66

EINECS 627-030-2

MOL File 145040-37-5.mol

Chemical Properties

Melting point 168-170?C
Boiling point 843.3±75.0 °C(Predicted)
Density  1.37±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≥15mg/mL
form  powder
pka pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
color  white to beige
λmax 304nm(EtOH)(lit.)
Merck  14,1739
InChIKey GHOSNRCGJFBJIB-UHFFFAOYSA-N
CAS DataBase Reference 145040-37-5(CAS Dat



Usage And Synthesis
Description

Candesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanoll but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, further blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Therefore, its mode of action is not through interfering with the pathways for angiotensin II synthesis. Candesartan cilexetil may lead to various kinds of adverse reactions including headache, back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, bronchitis, coughing, sinusitis, nausea, abdominal pain, diarrhea, vomiting, arthralgia and albuminuria. It should be warned that candesartan cilexetil might have remarkable fetal toxicity. Therefore, upon pregnancy, candesartan cilexetil should be discontinued. It could also cause hypotension for heart-failure patients.

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