Manufacturer Supply High Quality CAS 144689-78-1 Olmesartan Medoxomil

• CAS No.: 144689-78-1
• Formula: C29h30n6o6
• EINECS: 604-433-1
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Olmesartan Medoxomil
CAS	144689-63-4
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Olmesartan Medoxomil
Product Name Olmesartan Medoxomil

CAS 144689-63-4

MF C29H30N6O6

MW 558.59

EINECS 604-433-1

MOL File144689-63-4.mol

Chemical Properties

Melting point 180°C
Boiling point 804.2±75.0 °C(Predicted)
Density  1.38±0.1 g/cm3(Predicted)
Flash point 180°C
storage temp.  2-8°C
solubility  DMSO: soluble20mg/mL, clear
pka 4.15±0.10(Predicted)
form  powder
color  white to beige
Decomposition  180 ºC
InChIKey UQGKUQLKSCSZGY-UHFFFAOYSA-N
CAS DataBase Reference 144689-63-4(CAS DataBase Reference)




Usage And Synthesis
synthesize

Olmesartan Medoxomil can be synthesized in 8 steps from diaminomaleonitrile by successive reactions with trialkylorthopropanoate to access 2-propyl-imidazole-45dicarbonitrile, conversion of the two nitrile functions to the corresponding ethyl esters, followed by methylmagnesium bromide addition to give the corresponding 4-(1-hydroxyalkyl)imidazole derivative.

metabolism

Olmesartan medoxomil is rapidly and completely bioactivated by ester hydrolysis to its active metabolite, olmesartan, during absorption from the gastrointestinal tract. Olmesartan has an absolute bioavailability of approximatively 26%, a mean elimination half-life of 14 h in patients with hypertension and is not further metabolized. Olmesartan medoxomil is well tolerated, has a side-effect profile similar to that of placebo and unlike ACE inhibitors, the incidence of dry cough is rare.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.