Manufacturer Supply High Quality CAS 8005-44-5 Isatoic Anhydride

• CAS No.: 8005-44-5
• Formula: C8h5no3
• EINECS: 204-255-0
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02AL
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Isatoic Anhydride
CAS	118-48-9
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Isatoic Anhydride
Product Name Isatoic Anhydride

CAS 118-48-9

MF C8H5NO3

MW 163.13

EINECS 204-255-0

MOL File 118-48-9.mol

Chemical Properties

Melting point 233 °C (dec.) (lit.)
Boiling point 290.19°C (rough estimate)
Density  1,52 g/cm3
vapor density  5.6 (vs air)
refractive index  1.5510 (estimate)
Flash point 308 °C
storage temp.  Store below +30°C.
solubility  0.3g/l
pka 11.06±0.20(Predicted)
form  Powder
color  Beige to brown
Water Solubility  decomposes
Sensitive  Moisture Sensitive
BRN  136786
CAS DataBase Reference 118-48-9(CAS DataBase Reference)
NIST Chemistry Reference Isatoic anhydride(118-48-9)
EPA Substance Registry System 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)




Usage And Synthesis
Chemical Properties

BEIGE TO BROWN POWDER

Uses

Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

Definition

A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthraniliic aciid derivatives by reaction with hydrogen.

Preparation

Phosphorus tribromidee (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic aciid (0.1 mol;prepared by coupling anthranilic aciid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl etheer (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl etheer, and recrystallized from ethanol. Yield ca. 90%.

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