Pioglitazone HCl CAS 112529-15-4 Pioglitazone Hydrochloride

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02ALI
• CAS: 112529-15-4
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum1g, 50g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Pioglitazone hydrochloride
CAS	112529-15-4
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Pioglitazone hydrochloride
CAS:112529-15-4
MF:C19H21ClN2O3S
MW:392.9
EINECS:629-731-9
Mol File:112529-15-4.mol  
Melting point:193-194°C
RTECS XJ5813440
storage temp. Desiccate at RT
solubility DMSO: ≥10mg/mL
form powder
color white to off-white
Water Solubility Soluble in water (<1 mg/ml at 25°C), DMF, methanoll, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C).



Description

Description Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insuline dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thioureia. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insuline resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insuline, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insuline resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.

GuangZhou TongYi biochemistry technology Co.,LTD is a company specializing in active pharmaceutical ingredient (API), biology,plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and customer service. With the efforts of all the company's employees, it has established long-term and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic and foreign customers. With good comments, our company have made great progress.
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