Manufacturer Supply High Quality CAS 633-65-8 Berberine Hydrochloride Berberine HCl

• CAS No.: 633-65-8
• Formula: C20h18clno4
• EINECS: 211-195-9
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Berberine hydrochloride
CAS	633-65-8
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Berberine hydrochloride
Product Name Berberine hydrochloride

CAS 633-65-8

MF C20H18ClNO4

MW 371.81

EINECS 211-195-9

MOL File 633-65-8.mol

Chemical Properties

Melting point 204-206 °C (dec.)
storage temp.  Inert atmosphere,2-8°C
solubility  methanoll: soluble
form  Yellow powder
Colour Index  75160
color  Yellow powder
Water Solubility  SOLUBLE IN COLD WATER
BRN  3836585
InChIKey VKJGBAJNNALVAV-UHFFFAOYSA-M
CAS DataBase Reference 633-65-8
EPA Substance Registry System Berberine chloride (633-65-8)



Usage And Synthesis
Chemical Properties

yellow crystalline powder

Uses

antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant

Uses

An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Al so inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation o f chemotherapeutic drugs.

Uses

An ingredient in some commercial eyewash products.

General Description

A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
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