Supply Raw Material API CAS 148849-67-6 Ivabradine Hydrochloride / Ivabradine HCl

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02AL
• CAS: 148849-67-6
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Ivabradine hydrochloride
CAS	148849-67-6
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Ivabradine hydrochloride
CAS:148849-67-6
MF:C27H36N2O5.HCl
MW:505.05
EINECS:638-798-3
Mol File:148849-67-6.mol  
Melting point:193-196?C
alpha 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp. -20°C Freezer
solubility H2O: ≥5mg/mL (warmed)
form powder
color white to beige
optical activity[α]/D +5 to +9°, c = 1 in DMSO



Description
In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) - 80% (10 mM). .
Chemical PropertiesWhite to Off-White Solid
UsesSelective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal
UsesIvabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent
Usesangina therapeutic


GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
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