Manufacturer Supply High Purity CAS 32222-06-3 Calcitriol

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02ALI
• CAS No.: 32222-06-3
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Calcitriol
CAS	32222-06-3
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Calcitriol
CAS:32222-06-3
MF:C27H44O3
MW:416.64
EINECS:250-963-8
Mol File:32222-06-3.mol 
Melting point:119-1210C
alpha D25 +48° (methanollle)
Boiling point:474.91°C (rough estimate)
Density 1.0362 (rough estimate)
refractive index 1.4700 (estimate)
Flash point:14 °C
storage temp. 2-8°C
solubility Do you have solubility information on this product that you would like to share
pka14.43±0.40(Predicted)
form Solid
λmax265nm(lit.)
Merck 14,1644







Description
Calcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
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