Manufacturer Supply High Quality CAS 298-46-4 Carbamazepine

• CAS No.: 298-46-4
• Formula: C15h12n2o
• EINECS: 206-062-7
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02AL
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Carbamazepine
CAS	298-46-4
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Carbamazepine
Product Name Carbamazepine

CAS 298-46-4

MF C15H12N2O

MW 236.27

EINECS 206-062-7

MOL File 298-46-4.mol

Chemical Properties

Melting point 191-192 °C (lit.)
Boiling point 378.73°C (rough estimate)
Density  1.1099 (rough estimate)
refractive index  1.5906 (estimate)
Flash point 9ºC
storage temp.  2-8°C
solubility  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
pka 13.94±0.20(Predicted)
form  Crystals
color  Almost white
Water Solubility  pract. insoluble
Merck  14,1781






Usage And Synthesis
Overview

Carbamazepine (CBZ) is an irninostilbene derivative, structurally similar to the tricyclic antidepressants. Chemically. CBZ is a neutral, liposoluble compound that can easily pass the bloodlbrain barrier and other membranes in the body. Developed and marketed for the treatment of epileptic seizures and trigeminal neuralgia, CBZ has been utilized more and more frequently in the last decade to treat psychiatric disorders.
Carbamazepine was first evaluated as a potential treatment in manic depressive psychosis by Takezaki and Hanaoka (1971)[1], and Okuma et al. (1973)[2]. In 1979, Okuma et al.[3] performed the first double-blind trial of carbamazepine in comparison with the antipsychotic chlorpromazine in mania and found that 70% and 60% of patients improved respectively. A further placebo-controlled double-blind study replicated the antimanic properties of carbamazepine under controlled circumstances (Ballenger and Post, 1980). There have since been many studies demonstrating the efficacy of carbamazepine in treating the acute manic and depressive symptoms of bipolar disorder, as well as in prophylaxis

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