Supply Veterinary API Powder CAS 1397-89-3 Amphotericin B

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02AL
• CAS No.: 1397-89-3
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1g,10g,100g,500g,1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Amphotericin B
CAS	1397-89-3
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Amphotericin B
CAS:1397-89-3
MF:C47H73NO17
MW:924.08
EINECS:215-742-2
Mol File:1397-89-3.mol
Melting point:>170°C
alpha D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl)
Boiling point:804.34°C (rough estimate)
Density 1.34
refractive index 1.5280 (estimate)
storage temp. 2-8°C
solubility sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20?#x00b0;C. Stable at 37?#x00b0;C for 3 days.
pkapKa ~5.7(DMF/H2O) (Uncertain)
form powder
color yellow
Water Solubility <0.1 g/100 mL at 21 ºC




Description
Amphotericin B is a polyene macrolide antibiotic which was introduced into clinical medicine in 1955. It is primarily used for the treatment of serious systemic fungal infections. It is also used as an alternative drug for the treatment of drug resistant Leishmania. Amphotericin B is an effective drug, but its use is limited because of its toxicity. The advent of liposome encapsulated amphotericin may increase its use in multiresistant Leishmania in the future[1].
The mechanism of action of amphotericin is as yet not clear. In mycosis it binds to ergosterol present in fungal cell membranes. As a result, the drug forms pores or channels on the cell membrane which disturbs the membrane function allowing electrolytes (particularly potassium) and small molecules to leak from the cell resulting in cell death [2]. Oxidative damage to the cell may also be involved in this process [3]. Its mechanism of action in leishmaniasis may be similar to that in fungi.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
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