Manufacturer Supply High Quality CAS 117048-59-6 Combretastatin A4

• CAS No.: 117048-59-6
• Formula: C18h20o5
• EINECS: 206-141-6
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	COMBRETASTATIN A-4
CAS	117048-59-6
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

COMBRETASTATIN A-4
Product Name COMBRETASTATIN A-4

CAS 117048-59-6

MF C18H20O5

MW 316.35

EINECS

MOL File117048-59-6.mol

Chemical Properties

Melting point 84.5-85.5°C
Boiling point 490.3±45.0 °C(Predicted)
Density  1.184±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: >10mg/mL
pka 9.65±0.10(Predicted)
form  powder
color  off-white
Merck  14,2494




Usage And Synthesis
Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.
Chemical Properties

Crystalline Powder

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
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