Manufacturer Supply High Quality CAS 95233-18-4 Atovaquone

• CAS No.: 95233-18-4
• Formula: C22h19clo3
• EINECS: 928-470-0
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-79XQ
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Atovaquone
CAS	95233-18-4
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Atovaquone
Product Name Atovaquone

CAS 95233-18-4

MF C22H19ClO3

MW 366.84

EINECS

MOL File95233-18-4.mol

Chemical Properties

Melting point 216-2190C
Boiling point 535.0±50.0 °C(Predicted)
Density  1.349±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >10mg/mL
form  powder
pka 5.01±0.10(Predicted)
color  yellow
λmax 494nm(aq. Buffer)(lit.)
Merck  14,866


Usage And Synthesis
Antimalarial Agent

The hydroxynaphthoquinone atovaquone, which exhibits antimalarial and anti-Pneumocystis activity, is an electron transport inhibitor that causes depletion of the ATP pool. The primary effect is on the iron flavoprotein dihydro-orotate dehydrogenase, an essential enzyme in the production of pyrimidines. Mammalian cells are able to avoid undue toxicity by use of preformed pyrimidines. Dihydro-orotate dehydrogenase from Plasmodium falciparum is inhibited by concentrations of atovaquone that are very much lower than those needed to inhibit the Pneumocystis enzyme, raising the possibility that the antimicrobial consequences might differ in the two organisms. Although atovaquone was originally developed as a monotherapy for malaria, high level resistance readily emerges in Plasmodium falciparum when the drug is used alone. Consequently, atovaquone is now combined with proguanil.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
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