Manufacturer Supply High Quality CAS 138402-11-6 Irbesartan

• CAS No.: 138402-11-6
• Formula: C25h28n6o
• EINECS: 604-078-2
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Irbesartan
CAS	138402-11-6
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Irbesartan
Product Name Irbesartan

CAS 138402-11-6

MF C25H28N6O

MW 428.53

EINECS 604-078-2

MOL File138402-11-6.mol

Chemical Properties

Melting point 180-181°C
Boiling point 648.6±65.0 °C(Predicted)
Density  1.30±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: >25mg/mL
pka 4.16±0.10(Predicted)
form  powder
color  white to off-white
Merck  14,5083



Usage And Synthesis
Antihypertensives

Irbesartan is an angiotensin receptor inhibitor, angiotensin receptors are divided into AT1, AT2, irbesartan can inhibit Angtransform into Anby selectively blocking the AT1 receptor of Ang, specifically antagonize angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is 8500 times than that of AT2, it can inhibit vasoconstriction and aldosterone release by selectively blocking the binding Ang with AT1 receptor and result in the antihypertensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, and other hormone receptors, neither suppress the blood pressure regulation and the balance of sodium ion channels. Irbesartan can also reduce electrical remodeling of the myocardium, thereby reduce the mortality rate of patients with hypertension, it is the most effective drug for treatment of hypertension and cardiovascular disease.
Angiotensin antagonists (ARB) is applied to the clinical treatment of hypertension and diabetic nephropathy. At present, domestic drugs for treating high blood pressure are divided into angiotensin converting enzyme inhibitors (ACEI), calcium channel blockers, beta blockers and so on according to different working parts. By contrast, ARB has better antihypertensive effect, while Irbesartan is a new type of angiotensin antagonist which has clear antihypertensive effect, and has an important role in inhibiting left ventricular hypertrophy and protecting the kidneys.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
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