CAS 81129-83-1 Imipenem Cilastatin / Cilastatin Sodium

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02ALI
• CAS: 81129-83-1
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Cilastatin sodium
CAS	81129-83-1
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Cilastatin sodium
CAS:81129-83-1
MF:C16H25N2O5S.Na
MW:380.44
EINECS:279-694-4
Mol File:81129-83-1.mol  
Flash point:87ºC
storage temp. Desiccate at -20°C
solubility Very soluble in water and in methanoll, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetones and in methylenie chloride.
pkapKa1 2.0; pKa2 4.4; pKa3 9.2(at 25ºC)
form neat
 

Description
Chemical PropertiesWhite or light yellow amorphous, hygroscopic powder.
UsesEnzyme inhibitor.
DefinitionChEBI: The monosodium salt of cilastatin. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin sodium is therefore administ red with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to microbiologically inactive and potentially nephrotoxic products.
Biological ActivityDipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a K i value of 0.11 μ M. Inhibits metabolism of LTD 4 to LTE 4 and the hydrolysis of β -lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
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