Supply CAS 58-14-0 Pyrimethamine

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: TY-02AL
• CAS No.: 58-14-0
• Appearance: White Powder
• Einecs: 616-396-9
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Pyrimethamine
CAS	58-14-0
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Pyrimethamine
CAS:58-14-0
MF:C12H13ClN4
MW:248.71
EINECS:200-364-2
Mol File:58-14-0.mol
Melting point:233-234°C
Boiling point:393.35°C (rough estimate)
Density 1.2171 (rough estimate)
refractive index 1.6110 (estimate)
storage temp.  0-6°C
solubility Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanole R and 3 volumes of methylene chlorides R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
pkapKa 7(t=20.0) (Uncertain)
form neat
Water Solubility <0.01 g/100 mL at 21 ºC
λmax276nm(lit.)
Merck 14,7985




Description
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community [1].
The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis [1]. In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains [2]. This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
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