Manufacturer Supply High Quality CAS 53902-12-8 Tranilast

• CAS No.: 53902-12-8
• Formula: C18h17no5
• EINECS: 202-638-7
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02ALI
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Tranilast
CAS	53902-12-8
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Tranilast
Product Name Tranilast

CAS 53902-12-8

MF C18H17NO5

MW 327.33

EINECS

MOL File53902-12-8.mol

Chemical Properties

Melting point 166.2-168.2 °C (lit.)
Boiling point 465.23°C (rough estimate)
Density  1.3185 (rough estimate)
refractive index  1.5100 (estimate)
storage temp.  2-8°C
solubility  DMSO: 18 mg/mL
form  powder
pka 3.47±0.36(Predicted)
color  white to beige
Merck  14,9570
InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS DataBase Reference 53902-12-8(CAS DataBase Reference)



Usage And Synthesis
Chemical Properties

Pale Green Solid

Originator

Rizaben,Kissei Pharmaceutical Co., Ltd.,Japan,1982

Uses

Antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.

Uses

coronary vasodilator

Uses

Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases


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