Product name |
Metamizole Sodium Monohydrate |
CAS |
5907-38-0 |
Appearance |
white powder |
Assay |
99% |
Storage |
Cool and Protect from light |
Product Name:Metamizole Sodium Monohydrate
CAS:5907-38-0
MF:C13H20N3NaO5S
MW:353.37
EINECS:611-790-7
Mol File:5907-38-0.mol Melting point:221ºC
storage temp. 2-8°C
solubility H2O: soluble25mg/mL, clear
form powder
color white to beige
BRN 3865381
Metamizole (Dipyrone) is a potent analgesic and antipyretic. Metamizole inhibits prostaglandin synthesis in both the periphery and the central nervous system. Metamizole may act as a prodrug. It is rapidly hydrolyzed to N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA) which inhibit cyclo-oxygenase activity and can be further acylated with arachidonic acid forming compounds that bind to central and peripheral cannabinoiid (CB1 and CB2) receptors and TRPV1 receptors. It is believed that these metabolites play a major role in metamizole activity. Metamizole has been withdrawn from clinical use in several countries because of a side-effect of agranulocytosis in some patients.
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