Manufacturer Supply High Quality Levobupivacaine Hydrochloride CAS 27262-48-2 Levobupivacaine HCl

• CAS No.: 27262-48-2
• Formula: C18h29cln2o
• EINECS: 1308068-626-2
• Type: Synthesis Material Intermediates
• Appearance: White Powder
• Quality: Industrial
• Model NO.: TY-02AL
• Colour: White
• Package: Foil Bag
• Place: China
• Assay: 99%
• Shelf: 2 Years
• Transport Package: 25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
• Specification: 25kg/drum
• Trademark: tongyon
• Origin: China
• Production Capacity: 5000kg/Month

Product Description

 

Product name	Levobupivacaine hydrochloride
CAS	27262-48-2
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Levobupivacaine hydrochloride
Product Name Levobupivacaine hydrochloride

CAS 27262-48-2

MF C18H29ClN2O

MW 324.89

EINECS 1308068-626-2

MOL File 27262-48-2.mol

Chemical Properties

Melting point 254 °C (dec.)(lit.)
alpha  -12.5 º (c=2, water)
storage temp.  2-8°C
solubility  H2O: soluble20mg/mL, clear
form  powder
color  white to beige


Usage And Synthesis
Uses

(S)-(-)-Bupivacaine Hydrochloride is the salt analogue of a local anaesthetic used for epidural and intrathecal anaesthesia.

Description

Levobupivacaine was first launched in the US for the production of local anesthesia for surgery and obstetrics and for post-operative pain management. It is the (S)-enantiomer of the long acting, highly potent local anesthetic bupivacaine (Marcaine) that can be prepared by a three step sequence from (S)-pipecolic acid or from (S)-lysine by oxidative deamination and stereospecific ring closure to (S)-pipecolamide core structure. Levobupivacaine exhibits its long-acting local anesthetic effect by blocking neuronal sodium channel ion flow in nerve axons. Clinical studies demonstrated an efficacy and a general profile closely resembling those of the racemic bupivacaine currently in use; however, it produced an enhanced safety profile, in particular substantially reduced (about one-third) cardiotoxicity (less effect on myocardial contractility and QT, prolongation) and CNS depressive side effects. Onset and duration of blockade were also equivalent or even better.

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